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Adamantane & Dihydrazide-dihydrazone Group Compound, represented by A2P Care Pharmaceuticals LLP
The patented compound merges the therapeutic power of adamantane and dihydrazide-dihydrazone groups, known for their efficacy in treating Type 2 diabetes, neurological disorders like Parkinson’s and Alzheimer’s, and cancer. The dihydrazide-dihydrazone ability to address anti-diabetes and hypertension gives it an edge over existing treatments.
Overview
Our patented compound contains adamantane and dihydrazide-dihydrazone groups, both of which are known for their medicinal properties, as demonstrated in numerous literature reviews. The compound holds promise in the treatment of several diseases, especially cancer, neurological disorders, and diabetes.
Adamantane Derivatives:
Widely recognized for their efficacy in treating neurological conditions, such as Parkinson’s disease and Alzheimer’s disease, adamantane-based compounds are expected to play a pivotal role in the pharmaceutical industry in the near future. According to existing research, adamantane’s ability to mitigate neurological complications associated with Type 2 diabetes further strengthens its therapeutic potential.
Dihydrazide-Dihydrazone Compounds:
Known for their effectiveness against hypertension and diabetes, these compounds also exhibit various other pharmacological activities. The literature highlights the specific benefits of hydrazide/hydrazone derivatives in inhibiting alpha-glucosidase, a key enzyme related to Type 2 diabetes management.
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Patent Application No.: : 202221033544
PCT Patent No.: WO2023237924A1
HIPATONE
HIPATONE stands out as a revolutionary solution in the landscape of liver treatment for several compelling reasons. It harnesses the power of nature through a meticulous blend of extracts from Curcuma longa, Phyllanthus emblica, and Gymnosporea montana, each renowned for their hepatoprotective and medicinal properties. Not only does it address the symptoms of liver dysfunction like jaundice, but it also targets the underlying causes with its potent anti-inflammatory and antioxidant properties. By reducing liver inflammation and protecting liver cells from oxidative damage, Hipatone not only alleviates current symptoms but also prevents further deterioration of liver function.
The liver is the principal organ that is capable of converting drugs into forms that can be readily eliminated from the body. Given the diversity in use today and the complex burden they impose upon the liver, it is not surprising that a broad spectrum of adverse drug effects on liver functions and structures has been documented. The reactions range from mild and transient changes in the results of liver function tests to complete liver failure with death of the host. Many drugs may affect the liver adversely in more than one way, ascited below in several listings. The use of the following drugs requires careful monitoring of their effects on the liver during the entire course of treatment CLINICAL INDICATIONS LIVER DYSFUNCTION & JAUNDICE DETOXIFY LIVER THROUGH NATURAL SOURCE OF COMPOUNDS. This list is just a general guideline. Many drugs affect the liver to one degree or another and we can’t list all of them here; new drugs are always being approved for general use. “Liver Malfunction-Jaundice” – novel research composition signifies that HIPATONE®isanalytically and clinically proven safeand effective
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Patent Application No.: 153/MUM/2011 (NBA Approval awaited)
US Patent No.: US8431167B2
CARDIMODE
CARDIMODE stands out as a beacon of hope in the realm of cardiovascular health, offering a compelling solution backed by science and nature. With its unique blend of botanical ingredients, including Terminalia arjuna, Camellia sinensis, and Trikatu, this proprietary herbal medicine presents a promising avenue for individuals seeking to manage their cholesterol levels and safeguard their heart health. Through its targeted action on LDL (bad) cholesterol reduction and HDL (good) cholesterol elevation, this herbal supplement offers a holistic approach to cholesterol management, addressing a key risk factor for heart disease.
LITERATURE: UNDERSTANDING HEART ATTACK
A heart attack, or myocardial infarction, occurs when a blood vessel supplying the heart muscle is suddenly blocked by a blood clot. This blockage typically arises from the accumulation of cholesterol and other fatty substances within the blood vessel, forming plaque. Over time, plaque buildup narrows and hardens the arteries, a condition known as atherosclerosis. Reduced blood flow to the heart can lead to symptoms such as chest pain (angina) and, if left untreated, permanent damage to the heart muscle.
CARDIMODE Heart is vulnerable to a myriad of risk factors that contribute to heart disease. These include smoking, high cholesterol, high blood pressure, diabetes, obesity, and a sedentary lifestyle, collectively posing a significant threat to cardiovascular health. Plaque accumulation in the arteries, often triggered by elevated cholesterol levels and other risk factors, can culminate in partial or complete blockages, precipitating heart attacks. Additional risk factors encompass genetic predisposition, metabolic syndrome, heavy alcohol consumption, stress, sleep apnea, and certain medical conditions like preeclampsia. Embracing a healthy lifestyle, characterized by regular exercise, a balanced diet, smoking cessation, and effective stress management, is imperative in averting heart disease and mitigating the-likelihood of heartattacks.
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Patent Application Number: WO2013021302A
Masktag: Accessory Device For Face Coverings
Accessory Device for Face Coverings
The described invention pertains to an accessory device designed to address various issues associated with the use of face coverings, surgical masks, and filtering facepieces, especially in the context of the COVID-19 pandemic. Here’s an overview of the problem it aims to solve and the features it offers:
Problem Statement:
The widespread use of face coverings and masks in response to health emergencies, such as the COVID-19 pandemic, has highlighted several challenges and shortcomings associated with these protective devices. Some of the key issues include:
1. Difficulty in recognizing one’s mask after temporary removal, which poses a risk of using a contaminated mask.
2. Impaired recognizability of the wearer due to the partial coverage of the face by the mask, particularly exacerbated when wearing additional accessories like glasses or hats.
3. Accumulation of unpleasant odors inside the face covering, primarily caused by the user’s breath.
4. Build-up of microbial and viral load within the face covering due to prolonged use and favorable microclimatic conditions, potentially leading to health risks.
CARDIMODE Heart is vulnerable to a myriad of risk factors that contribute to heart disease. These include smoking, high cholesterol, high blood pressure, diabetes, obesity, and a sedentary lifestyle, collectively posing a significant threat to cardiovascular health. Plaque accumulation in the arteries, often triggered by elevated cholesterol levels and other risk factors, can culminate in partial or complete blockages, precipitating heart attacks. Additional risk factors encompass genetic predisposition, metabolic syndrome, heavy alcohol consumption, stress, sleep apnea, and certain medical conditions like preeclampsia. Embracing a healthy lifestyle, characterized by regular exercise, a balanced diet, smoking cessation, and effective stress management, is imperative in averting heart disease and mitigating the-likelihood of heartattacks.
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Patent Application Number: WO2013021302A
Patent Protected Modular Urinal for Bed Ridden People
About Us
IIPRD is representing Peeshcute in an IP Licensing mandate for a technology which Empowers Convenience and Independence for those with limited mobility issues.
Peeschute’s modular urinal tech has been carefully designed considering factors like non-invasiveness, ease of use, hygiene, sustainability, reduced dependability and reduced risk of infections.
- Established in 2018, Peeschute is a renowned brand specializing in developing innovative solutions for sanitation.
- Peeschute has developed urinal products for travel, healthcare/homecare and outdoor spaces.
- Peeschute’s flagship product includes pocket sized disposable urine bags which solidifies up to 850 ml of urine instantly to keep it leak proof, odorless and hygienic.
- Peeschute’s products have been accoladed with national and international attention including media, organizational collaborations with government and non-government bodies.
Patent Application No: 202221026004
Registrations Design Number: 373040-001 and 373041-001
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“Resoil” presented by Envit Ltd.
ReSoil® is an internationally patented, groundbreaking remediation solution that enables closed-loop removal of heavy metals from contaminated soils through a zero-emission process with no wastewater, while preserving soil as a natural substrate.
• Soil contamination with heavy metals is a global problem.
• Heavy metals include toxic metals such as lead (Pb), cadmium (Cd), copper (Cu) and zinc (Zn) as well as toxic metalloids such as arsenic (As) and antimony (Sb).
• Soils absorb decades of pollution from industry, intensive agriculture, traffic, waste, etc. Heavy metals are not degradable and remain in the soil.
• According to a recent conservative estimate, there are 2.8 million potentially contaminated sites in the EU (EEA, 2023).
• In China, 1/6 of the total cultivated area is contaminated with heavy metals (Yao et al., Proc Env Sci 2012, 16, 722-729).
• In New York, 71% of garden soils exceed the limits for lead and arsenic (Chenget al., Soil Sci 2015, 180, 167-174).
• Arsenic and lead are the 1st and 2nd most dangerous environmental pollutants
(ATSDR 2017).Lead distribution in surface soil of the conterminous United States (USGS 2014).
• Arsenic is highly toxic, long-term exposure can cause cancer.
• Lead is a neurotoxin; in the USA, the average lead-related loss of cognitive ability was 2.6 IQ points per person as of
2015 (McFarland et al. PNAS 2022, 119, e2118631119
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Patent Application Number: WO2022184903
Machine to Dispose off used Sanitary napkins chemically
Current methods of disposal and associated danger
1. Flushing and burying
• leads to blockages, plumbing problems
• outer layer of sanitary napkin is non-degradable
• collection of napkins in heaps block the pipeline
• pollute streams and rivers
• causes hormonal changes in wildlife – enable harmful organisms in the food chain
2. Incineration
• Harmful gas emissions: dioxin, furan, nitrogen oxides, sulphur dioxide, hydrochloric acid, mercury
• Ash produced contain heavy metals like lead, cadmium, copper, zinc
• Dioxins: cancer, immune system damage, reproductive and developmental problems.
• Halogenated hydrocarbons, acid gases – impair lung function.
Objectives of the new machine
• Disposal of sanitary napkins properly, thereby wiping out the risks involved in flushing, burying, and incineration.
• Reduce pollution and health hazards of conventional methods of sanitary waste disposal.
• Reduce cost for proper disposal of sanitary napkins, tampons, baby diapers and under pads.
• Simplify the process of sanitary waste disposal.
• Help in solving greatest problem people face daily.
Key Points of the machine
• One machine- can be used for sanitary napkins, tampons, baby diapers and under pads. (If a method to choose the option while
using the machine is implemented)
• Can be manufactured both – domestic (for households) and industrial size (waste disposal plants/ panchayats)
Patent Application Number: 298227
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DIABETES CARE – MEDICAL DEVICE FOR TISSUE OXIMETRY
The Opportunity
Blackhawk Technologies, LLC is exclusively representing HyperMed Imaging Inc. (the“Company”) to monetize its’ assets related to a Medical Device for Tissue Oximetry for Diabetes Care. The offering includes an FDA cleared product used by clinicians and backed by 24 patent families comprising of 62 total assets.
The Company’s pioneering technology has been in service since 2006 and has been validated in third-party published papers that assessed oxyhemoglobin, deoxyhemoglobin, and oxyhemoglobin saturation in superficial tissue for diabetic patients. The Company’s FDA 510(k) cleared product, Hyper View™, quickly determines levels of oxyhemoglobin, deoxyhemoglobin and oxygen saturation in superficial tissue in a small and portable configuration.
The Company seeks a strategic acquirer/licensee with both resources and channels to fully commercialize Company’s IP assets.
The Unmet Medical Need
Most medical exams need quick and accurate determination of superficial tissue oxygenation. For example, complications in diabetes and/or peripheral arterial disease increases risk of lower limb ischemia, chronic wounds, amputation or even death.
• Over 420 million people worldwide (1 in 11 people) have diabetes and the number is increasing rapidly.
• More than 29 million Americans have diabetes. Another 86 million have prediabetes, which is 1 in 3 US adults.
• 8.5 million Americans have peripheral arterial disease and among them nearly 2 million people in the USA are living with limb loss.
• The main causes are vascular disease (54%), including diabetes and peripheral arterial disease.
• Approximately 185,000 amputations occur in the United States each year, costing over $8 billion.
• People with diabetes are at greater risk for severe peripheral arterial disease and are five times more likely to require an amputation.
• It is estimated that a low
Hyperspectral Imaging Benefits
• Non-contact color-coded images depicting concentrations of oxyhemoglobin & deoxyhemoglobin, and oxygen saturation without injectable contrast agents.
• Readings are predictive of wound healing and can be used in screening for peripheral vascular disease.
• Software tools allow clinicians to analyze specified areas within the image to localize ischemic tissue.
• Offers improved patient care with speed, ease of use, and clinical efficiency without injectable contrast or physical contact of the device with the patient.
• Safe, using visible light and spectrometer imaging to quantify light absorption in hemoglobin molecules for rapid analysis without leaving the exam room.
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IONOJET TM
Has developed a proprietary device (“IonojetTM”) that generates nitric oxide (“NO”) from atmospheric air in the form of a high-energy plasma/NO stream and delivers it to targeted locations of the body.
The plasma/NO stream has been shown in investigations to date:
(i)to be non-toxic
(ii) to generate NO activity up to 3 cm below the skin
(iii) to stimulate sustained biological activity in tissue for up to an hour after delivery of the therapy, and
(iv) to penetrate and disrupt biofilm
Has identified over 40 target indications in seven clinical areas based on NO’s recognized ability to:
- Increase blood flow
- Destroy pathogens (bacterial, viral and fungal)
- Regenerate tissue
- Control pain and inflammation
Has completed a dose-ranging feasibility clinical trial in the U.S. for initial target indication (Diabetic Foot Ulcers, “DFU”) to identify optimal dose & demonstrate preliminary safety/efficacy data for the device.
- Has completed PoC studies in certain target indications
- Intends to initiate PoC studies in a number of additional indications
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Nutrition Innovation In Singapore
White refined sugar is almost pure sucrose. This sucrose is consistently shown in research to be quickly absorbed into the blood stream causing rises in blood sugar levels. This in turn has contributed to the global obesity and diabetes crisis.
The Nucane™ specification of raw sugar is scientifically tested to ensure that this absorption is reduced.What the unique Nucane™ process achieves is to retain at a high level the natural organics, antioxidants and polyphenols that exist in raw sugar cane, delivering a carbohydrate that is less processed, less refined, and which has been demonstrated scientifically to reduce the metabolism of sugar into the blood stream when consumed.
This means that it is a low glycemic sugar when tested to the internationally agreed ISO 26442:2010 method.Just as importantly, our technology system ensures that Nucane™ is precise and consistent at industrial scale in primary sugar mills around the world. By eliminating the refining process and applying the Nucane technology at sugar mills, Nucane™ is a less processed, less refined, high in polyphenols specification of raw sugar which has been tested to be low glycemic to international standards.
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Pop Test & Palisades Therapeutics Companies
WELLNESS Screening/Monitoring
Diabetes
Diagnosed and undiagnosed diabetes in the United States, all ages, 2012, Total: 29.1 million people or 9.3% of the population have diabetes. Diagnosed: 21.0 million people. Undiagnosed: 8.1 million people. (27.8% of people with diabetes are undiagnosed)
NASH/NAFLD
Prevalence of NAFLD and NASH is higher than estimated previously. Hispanics and patients with diabetes are at greatest risk for both NAFLD and NASH. Up to 80% of obese people have the disease. Non-alcoholic steatohepatitis (NASH) is the most extreme form of NAFLD, and is regarded as a major cause of cirrhosis of the liver of unknown cause. About 12 to 25% of people in the United States has NAFLD. While NASH affects between 2 to 5% of people in the United States.
Cholesterol
Percent of adults age 20 years and over with high serum total cholesterol (greater than or equal to 240 mg/dL): 13.4% (2009-2012)
Gout
Gout prevalence swells in U.S. over last two decades; Increase in obesity and hypertension are likely contributors. Prevalence of gout in the United States has risen over the last twenty years and now affects 8.3 million Americans.
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Compound for Pancreatic Cancer
The novel compound focuses on inhibiting tumor growth and synergy with chemo in select cancers by targeting Pancreatic Cancer Stem Cells (PanCSCs), which could be an ideal therapy to overcome chemoresistance. The compound tends to be a cutting edge science focused on large critical disease markets. This anti cancer compound invented by Dr. Gurdial Singh has the potential to be a life saving therapy for aggressive cancers.
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Broad Spectrum Antiviral Polysaccharide_Microbial Technology
Technology relates to a Broad-Spectrum Antiviral Polysaccharides from the marine, heterotrophic, microalgae called thraustochytrids, these microalgae also produce the omega-3 fatty acid, DHA. Therefore, this is an economical process to produce two valuable compounds from safe microorganisms. Proposed Technology addresses following Viruses: Enterovirus, Retrovirus, Cytomegalovirus, Adenovirus, Herpes simplex virus.
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Novel Terpenoidal Based Analogue Of Vasicine With Multiple Therapeutic Activities
Invention relates to the novel compound of formula I and pharmaceutically acceptable salts thereof and use of the said novel compound for the treatment of asthma. The invention involves design, synthesis and biological evaluation of a novel terpenoid based compound and pharmaceutical acceptable salts thereof which possess multiple therapeutic effects like bronchodilatory, anti- allergic and anti-tussive effects.
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Preparation Process For Protease Inhibitor Intermediates
Invention relates to Preparation Process of racemic 6, 6-dimethyl-3-azabicyclo-[3.1.0]-hexane, a key raw material for the preparation of key intermediate (1R, 2S, 5S) – methyl 6,6-dimethyl -3-azabicyclo [3.1.0] hexane-2 carboxylic acid for the class of inhibitors of Protease such as Boceprevir. The process is efficient and economic as in this preparation process lithium aluminium hydride is not used.
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Nutritional Supplements From Green Leafy Vegetables
Technology relates to a Nutritional Supplements from Green Leafy Vegetables to source all nutritional requirements through normal daily food intake. The products have key ingredients such as beta carotene, xanthophylls, chlorophylls, alpha tocopherol among others from green vegetables and the products are used for relief from stress, acidity, nausea, for weight management and also have health benefits for patients suffering from trauma and other health related issues.
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Mouth Exercising Device For Oral Submucuos Fibrosis
Invention relates to a Mouth Exercising Device for Oral Submucuos Fibrosis caused due to betel nut chewing in the form of gutkha, and other tobacco products. The technology is patent pending, prototype of the device as a proof of concept was developed and clinical trials are in progress. The report of the clinical trial is accepted for presentation at meeting of International ”Association for Dental Research” USA in March 2013.
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Polymer Superabsorbent For Removal Of Toxic Components
Technology relates to a polymer for detection, removal and recovery of toxic components such as volatile organic compounds (VOCs), polycyclic aromatic hydrocarbons (PAHs) and other aromatic pollutants. The Polymer comprises a plurality of tetra phenyl monomer units and its preparation process is also disclosed.
Highly Specific Antibodies Against Phosphorylated NPM1
Technology relates to an antibody against phosphorylated Ser-125-NPM1, its production method and use of highly specific antibodies against phosphorylated NPM1. NPM1 is identified as a novel substrate for Aurora kinases A and B, both acting on same site, Ser125 on NPM1 for phosphorylation during the onset of mitosis. Technology also discloses a method and kit used for production and usage of polyclonal antibodies specifically targeting Ser125 phosphorylated NPM1 along with pharmaceutically acceptable carrier could be used in diagnosis of tumor.
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Slow Release Semiochemical Composition, Dispenser
Technology relates to a composition and a method of preparation of composition comprising substrate, semiochemical and an anti-oxidant, optionally along with additive. Invention also relates to a device or a trap comprising the composition. The composition results in controlled release of semiochemicals. The composition helps in protection of plants from pests.
Method Of Self Assembling Naphthalene Diimide Derivatives
Technology relates to a method of self-assembling naphthalene diimide derivatives, the proposed technology discloses the self-assembled nano, meso or micro structure of naphthalene diimide derivative with phenyl alanine, tryptophan, methyl ester of tryptophan or phenylalanine, and peptide containing tryptophan or phenyl alanine or methyl ester of phenylalanine or tryptophan as imide side chain. The proposed technology got wide range of applications in Biological, biomedical, supramolecular, and anticancer agents.
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Novel Liposomal Pharmaceutical Formulation For Enhanced Drug Delivery For Anticancer Agents
Technology relates to a novel liposome formulation for delivery of anticancer agents such as Docetaxel (DTX) with significantly higher antitumor efficacy, preparation is simple and easy to scale up. The present formulation significantly improves the biopharmaceutics of difficult-to-deliver drugs such as DTX. About 10-15-fold and 20-25 fold increase in the circulation half-life and mean residence time was observed upon incorporation of DTX in TPGS-Liposomes, as compared to Taxotere.
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Novel Nutraceutical & Pharmaceutical Ingredients From Moringa Oleifera
Invention relates to a novel nutraceutical products isolated and characterized from Moringa oleifera. The process involves the cold extraction of moringa seeds, which gives five different nutraceutical ingredients. This invention describes the nutraceutical and pharmaceutical activity of the products which have been isolated by a series of extraction techniques. One of the products extracted in such process is a complex characterized to be a type of glucosinolate combined with cationic protein, which is found to be very active against diabetes. The other product extracted can be used for wound healing.
Preparation Process Of Retigabine And Its Intermeadiates
Invention relates to an efficient, economical and industrially viable process for the preparation of 2-amino-4-(4-fluorobenzylamino)-1-ethoxycarbonylaminobenzene (Retigabine). The process replaces genotoxic and potentially hazardous hydrazine hydrate as a deprotecting agent by new set of deprotecting agents . This technology also relates to the preparation processes of Retigabine intermediates.
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Isolation Process Of Docosahexaenoic Acid In Its Directly Compressible Powder Form
Technology relates to a Docosahexaenoic acid (DHA) in its free fatty acid form which is directly compressible and a process of isolation from oils, and fats of natural origin having Docosahexaenoic acid attached to triglycerides. The DHA produced by this method is free from triglycerides, has purity of more than 90 percent, and the DHA free in its free fatty acid powder form offers excellent bioavailability and stability at room temperature.
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Novel Process Of Isolation And Characterisation Of Nutraceutical Ingredients From Moringa Olefira
Invention relates to a novel process of isolation and characterisation of nutraceutical ingredients from moringa olefira. The proposed process involves: separation of oil & cake from the seed powder by cold expression, followed by extraction, freezing, evaporation by spray drying or freeze drying. The products isolated by using this process can be used against diabetes, and wound healing among other nutraceutical applications.
Smartphone Based Urine Analysis System
Technology relates to a smartphone based urine analysis system that can measure 10 parameters in urine. Urinalysis can diagnose and help manage up to 25 medical conditions, including diabetes, kidney and liver problems and common infections like UTIs. The system consists of an app that reads color changes in strips dipped in the test sample, and a peripheral kit to make this happen reliably.
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Intralock Intravenous Cannula
Technology relates to an Intralock Intravenous Cannula solving the problems with the existing intravenous cannula products using a concept of non-return valve, instead of using a hard plastic as the cannula valve. Using this system clotting of blood and oozing of blood is prevented.
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Novel Bioactive Lipids From Ethylene Glycol
Invention relates to novel bioactive lipids, which are obtained from ethylene glycol by trans esterification of fatty acid esters with ethylene glycol. The novel lipid products obtained from ethylene glycol are bioactive and can be used as anti-bacterial, anti-fungal, anti-inflammatory, wound healing, anti-obesity and as anti-cancer agents and can also be used as non-ionic surfactant.
Preparation Process Of Optically Pure Milnacipran
Invention relates to process for preparing optically pure milnacipran and their pharmaceutically acceptable salts using D/L- mandelic acid as resolving agents. The process is simple and economical as it uses low cost commercially available resolving agents and industrially scalable.
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Isolation Process Of Eicosapentaenoic Acid (EPA) In Its Directly Compressible Powder Form
Technology relates to an Eicosapentaenoic acid (EPA) in its free fatty acid form which is directly compressible and a process of isolation from oils, and fats of natural origin having Eicosapentaenoic acid (EPA) attached to triglycerides. The EPA produced by this method is free from triglycerides, has purity of more than 90 percent, and the EPA free in its free fatty acid powder form offers excellent bio availability and stability at room temperature.
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Inhibitors Of Histone Methyltransferase
Invention relates to the field of small molecule modulators. Particularly relates to the site specific inhibitors of histone methyltransferase and their preparation process. These compounds are isolated from pomegranate fruit and can be used as a lead compounds to develop anti-neoplastic or anti-HIV therapeutics.
US Patent Number: 7875741
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Agriculture, Crop, Soil And Bio Technologies
Indian company expert in the field of agriculture and bio technology has developed various technologies relating to Microbial formulation for promoting plant growth, Soil health rejuvenator, Microbial method for reclamation of sodic alkali soils, Ready to use viable product of the bio-decomposer agent for applications in stubble management, liquid bio fertilizer of phosphate solubilizing bacteria, process for biodegradation of petroleum waste products and petroleum sludge.
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Modulators Of Histone Acetyltransferase
Invention relates to the field of novel anticancer agents. Particularly relates to the use of certain benzoic acid and benzamide compounds as modulators of enzymes histone acetyltransferases. These compounds are involved in gene expression and cancer and also such compounds are used for the treatment of diseases due to defects in gene regulation predominantly cancer.
Patent Application Number: 7750047
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Self-Assembling Synthetic Cyclic Dipeptide
Invention relates to a preparation of cyclic dipeptide 3,6-diphenylpiperazine-2,5-dione and its nano, meso and micro structures comprising steps of condensing fluorenylmethyloxycarbonyl protected phenylglycine with an ester using coupling reagent to obtain protected dipeptide and deprotecting the protected dipeptide to obtain the cyclic dipeptide. The technology has application in various field such as for Inhibiting fibrillization in neurodegenerative diseases, Radiography, as template for differentiation of cells, as optoelectronic component Imaging, and as a Biomaterial such as Suture, Fabric and bandage material.
Patent Application Number: WO2011055247
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Soil Health Rejuvenator And Organic Matter Enhancer
Technology relates to the composition comprising of viable cells of microorganisms with bio-decomposition and rejuvenation property enhancing organic matter in agricultural soil which thereby enhances crop productivity and develop immunity towards plant diseases. A soil conditioner using microorganism for reducing the harmful effect of chemical amendments. The soil conditioner improves the content of organic matter of the soil and enhances immunity of the plants to prevent pests and diseases.
Patent Application Number: WO2010122501
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HTS (High Throughput Screening) For Identifying Small Molecule Inhibitors For HIV-1 Tat
Invention relates to a method of identifying small molecule inhibitors for the HIV TAT using a high throughput screening (HTS) assay, which will aid in the development of new class of HIV drugs. It relates to a TAT-inducible GFP anti RFP shRNA vector, vector combinations, recombinant cell having vectors comprising nucleotide sequence sets. The technology can effectively distinguish between a genuine anti-viral inhibitor and a cytotoxic molecule and thus , decreases the number of false hits.
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Three-Dimensional Stereomicroscope
Technology relates to a Three-Dimensional Stereomicroscope with a variable inter-objective distance to provide an increased field and depth of vision. Using the proposed technology problem of restricted image formation is solved, and the proposed device can be used for industrial, laboratory and medical operation in a easy and safe way.
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Microbial Formulation For Widespread Uesd In Agricultural Practices
Technology relates to a microbial formulation for promoting plant growth comprises a mixture of beneficial microbial isolates for customized solution of soil health related problem. The microbial formulation provides protection against plant pathogens, lower the need for nitrogen containing fertilizers and soluble minerals, and make plant valuable nutrients available, and thus reduce or eliminate the need for chemical pesticides and chemical fertilizers.
Patent Application Number: WO2010109436
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Accurate Needle Insertion Surgery
Technology is relevant to manufacturers of surgical medical equipment, specifically medical imaging devices. System uses innovative three-dimensional C-arm X-ray (fluoroscope) imaging to improve the accuracy of needle insertion guidance for increasing the success of kidney stone removal (percutaneous nephrolithotomy) as well as other needle insertion procedures.
Patent Application Number : WO2010097697
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Extended Release Formulation
Invention relates to an extended release formulation of a broad spectrum macrolide antibiotic such as clarithromycin comprising a unique blend of polymer matrix using two different grades hydroxypropylmethyl cellulose, sodium carbonate and other excepients in an optimized ratio to achieve an extended or delayed drug release profile up to 12 hours without any chemical interaction between drug and excepients.
Patent Application Number: 552/KOL/2010
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Process For Whey Treatment In Dairy Industry
Invention relates to a whey treatment in dairy industry collecting the whey as wastewater from cheese and/or paneer production section, performing chemical pre-treatment step using a combinations of chemical coagulants and adsorbents, passing through an integrated membrane cassette for whey protein concentration and recovery.
Patent Application Number: 1428/KOL/2011
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Ethosome Compositions Of Curcumin For Transdermal Delivery
Invention relates to Ethosome compositions for transdermal drug delivery comprises therapeutically effective amount of curcumin, phospholipon 90H, cholesterol, propylene glycol and ethanol. The process comprises dissolving curcumin, cholesterol and phospholipon 90H in ethanol and propylene, addition of distilled water, cooling homogenisation to obtain the ethosome composition.
Patent Application Number: 1734/MUM/2011
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PROCESS FOR DETECTING HUMAN HAEMOGLOBIN VARIANTS
Invention relates to a process for detecting the presence or absence of human hemoglobin HbAO and/or HbE in a sample by way of nanoparticle -hemoglobin interaction. Process for detecting the presence or absence of human hemoglobin HbAO and/or HbE in a sample comprises treating sample with copper nanoparticle, formation of moderate precipitate or aggregate indicating the presence of human haemoglobin HbE and the process has diagnostic ability to differentiate among proteins by the extent of their unfolding.
Patent Application Number: 39/DEL/2011
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Nanocrystals Of Lovastatin
Invention relates to a process for preparation of nanocrystals of poorly water soluble drugs to increase the solubility and dissolution rate and bioavailability. It is an improved process for preparation of nanocrystals of lovastatin (LVS) to increase the solubility and dissolution rate and bioavailability. Lovastatin is a member of the drug class of statins, used for lowering cholesterol.
Patent Application Number: 1215/MUM/2011
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Synthetic Lung Surfactant
Technology relates to an inexpensive and extremely effective synthetic lung surfactant, which has the potential to save the lives of babies, children and adults suffering with any of a range of respiratory and lung ailments. Synthetic formulation consisting of a combination of phospholipids and synthetic peptides which may be administered in liquid form or nebulised/aerosolised.
Patent Application Number:: WO2011/104621
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Modulators Of Histone Acetyltransferase
Invention relates to the field of novel anticancer agents. Compounds shown in figure are useful for the treatment of cancer, AIDS, HIV infections and asthma.
Patent Application Number: 7332629
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Stereo-Selective Preparation Of 3-Hydroxy-3-Phenylpropionitrile
Technology relates to a Chemoenzymatic process for the stereoselective preparation of both (R) and (S) enantiomers of 3-hydroxy-3-phenylpropanenitrile, useful as a key intermediate for synthesis of (S)-Fluoxetine, (R)-Tomoxetine and cognant compounds.
Patent Application Number: WO/2002/057475, Granted Indian and UK Patent and pending JP Patent.
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Polyisoprenylated Benzophenones As Inhibitors Of Histone Acetyltransferases
Invention relates to Polyisoprenylated benzophenones and their isomers as inhibitors of histone acetyltransferases. These compounds are useful as biological switching molecules for evaluating the role of p300 and PCAF in cellular functions and also may be useful as new chemical entities for the development of anticancer drugs.
Patent Application Number: 7402706
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Stereo-Selective Preparation Of 3-Hydroxy-3-(2-Thienyl) Propanenitrile
Technology relates to a Chemoenzymatic process for the stereoselective preparation of both enantiomers of 3-hydroxy-3-(2-thienyl) propanenitrile, which are optically pure intermediates for the synthesis of both enantiomers of duloxetine in high enantiomeric excess.
Patent Number: 7045341, Granted Indian and EP Patent.
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Lutein From Oleoresin
Invention relates to a Process for isolating, purifying and formulating commercial grade lutein paste from oleoresin. Process comprises dissolving oleoresin in alcohol to obtain xanthophylls esters , hydrolyzing with base, quenching, drying ester layer and finally mixing the obtained lutein crystals with non-water soluble fractions to obtain stable lutein paste. Lutein thus prepared can be made stable during storage without use of chemical additives and also available at viable prices.
Patent Application Number:7179930
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Chemoenzymatic Process For Stereoselective Preparation Of (R)-GABOB And Carnitine
Technology relates to a chemoenzymatic process for Stereoselective preparation of (R)-GABOB and Carnitine comprising tosylating 3,4-dihydroxybutanenitrile, resoluting racemic 3-hydroxy-4-tosyloxybutanenitrile and coverting the racemate to (R)-GABOB and Carnitine.
Patent Application Number:7816119
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Preparation Process Of Chromium Dioxide And Other Oxides
Invention relates to a process for preparing chromium dioxide and other oxides of chromium. Hard sintered chromium oxide can be obtained without introducing any detectable impurity phase and the obtained chromium oxides and composites have shown significant negative magnetoresistance near room temperature. Chromium oxides have application in magnetic recording application.
Patent Application Number: 7276226
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Chemoenzymatic Process For Stereoselective Preparation Of (R)-GABOB
Technology relates to a chemo enzymatic process for the stereo selective preparation of both enantiomers of 3-hydroxy-4-trityloxy butanenitrile and their effective application in the preparation of (R)-GABOB through an enantioconvergent process comprising transesterifying 3-hydroxy-4-trityloxybutanenitrile, transforming optically pure 3-acetyloxy-4-trityloxybutanenitrile to (R)-GABOB and transforming 3-hydroxy-4-trityloxybutanenitrile to (R)-GABOB.
Patent Application Number: 7374926 , Granted EP, Indian and JP patent.
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Prosthetic Devices Coated With Heated Cross-Linked Fibrin
Invention relates to methods of coating the surface of prosthetic devices with fibrin and drying the fibrin-coated prosthetic devices at moderately-high temperatures for extended periods of time under low atmospheric pressure to obtain prosthetic devices coated with stable cross-linked fibrin capable of binding cells and thereby capable of integrating into tissues.
Patent Application Number: WO2010/131249
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Preparation Process Of An Intermediate Used In Synthesis Of Atorvastatin
Invention relates to a impurity free preparation process of 4-fluoro-.alpha.-[2-methyl-1-oxopropyl]-y-oxo-n-beta-diphenylbenzenebutanamide, a key intermediate for the synthesis of Atorvastatin. Atorvastatin a drug useful for lowering blood cholesterol, stabilizing plaque and preventing stroke through anti-inflamatory and other mechanisms.
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Iontophoretic Device For Drug Administration To The Eye
Invention relates to a drug delivery device which is portable, easy to use iontophoretic device that ejects a high content of drug from a soft gel upon application of a low current. The device is intended to safely apply large amounts of drug to the posterior ocular tissues and to replace the use of recurrent intravitreal injections, therefore preventing the pain and complications that patients are forced to deal with today.
Patent Application Number: WO2005/084748
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Process For The Production Of Low Cholesterol Ghee
Invention relates to a process for preparation of ghee of reduced cholesterol from melted butter serum without the homogenization. Process involves adding Beta cyclodextrin 1 % to 10 % by weight of total fat content in the butter serum, adding to the melted butter serum at a temperature in the range of 35 oC to 65 oC, agitating, separating cholesterol-beta cyclodextrin complex from the butter serum and collecting concentrated butter fat serum of reduced cholesterol content and heating.
Patent Application Number: WO2010/140164
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Reusable Transition Metal Complex Catalyst For Preparing 3,3-Diaminobenzidine
Invention provides a reusable transition metal complex catalyst. Transition metal complex catalyst is useful for the preparation of high pure quality 3,3-diaminobenzidine and its analogues. Tetraaminobiphenyl prepared using transition metal catalyst is a valuable intermediate for example used as a monomer in the preparation of polybenzimidazole polymers.
Microfluidic Test Systems With Gas Bubble Reduction
Invention relates to a reservoir for use in testing a liquid as part of a microfluidic testing system includes testing chamber, a liquid inlet coupled to the testing chamber and a gas outlet. This system reduces or prevents the presence of gas bubbles and also can be utilized in a variety of testing regimes.
System For Optically Analyzing A Substance
Invention relates to a microfluidic analysis system for optically analyzing a substance includes a light source having a plurality of selectable single-wavelength light sources, a substance presentation member optically coupled to the light source and an optical detection system. This system is less expensive, easy to transport and doesn’t require large sample volumes.
